Nix/Guix are essentially the Mod Organizer of GNU/Linux distributions.
For those here who aren’t Skyrim modding enthusiasts, ModOrganizer was a tool that came around a few years after the game was initially released. Bethesda games have always had amazing moddability, so there were a number of tools that were used for installing, organizing, and managing various mods. Several of these (such as Nexus Mod Manager) were fairly entrenched.
They all worked similarly, pick the mod and have the manager throw the files into your Skyrim directory while adjusting any configuration files needed. It worked, but generally unless you had some experience you were probably going to have to occasionally wipe your Skyrim directory and start from scratch because you messed something up.
Then along came Mod Organizer (and eventually Mod Organizer 2, but that’s a separate story). Mod Organizer was ahead of its time. Instead of just dumping everything into the Skyrim directory, it instead built a virtual filesystem that first loaded the Skyrim files, then linked in all the mods as well, using the configuration that you designed. Then, when ready, it would launch the game from this virtual environment.
Mods could now be swapped/reordered/changed as needed, and it was now possible to set up numerous profiles that used any number of different mod configurations, and best of all, it did all of this while leaving your base Skyrim directory untouched and pristine.
Eventually additional tools like Wabbajack were added that utilized Mod Organizer to its full extent, granting the ability to do one-click installs of massive mod configurations that completely transformed the game experience. It took awhile, but eventually Mod Organizer became the default/go-to tool for Skyrim modding.
I find Guix/Nix eerily similar to Mod Organizer in terms of its value proposition. I also hope that it sees a similar timeline, where once everyone sees the benefit they eventually adopt it as the new standard.
I’m not yet sure if Guix Home is the system’s Wabbajack, but I’ve been using Guix as my main workstation for about a month now and really love the system. There are still plenty of warts, but I love the potential that the system has.