I wrote a channel that provides some utilities to use guix to reproducibly tangle org files into the store.
The main reason I wrote it was because I wanted to define my home configuration in =home.org=, which is working!
https://git.sr.ht/~clone/guix-org/tree/master/item/readme.org
This is still really early stages and I plan to add more helpers for other use cases and improve it. Definitely appreciate any feedback.